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pentobarbital will minimize the extent or outcome of linagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Use of other therapies is strongly advised when linagliptin would be to be administered with a CYP3A4 inducerpentobarbital will reduce the level or outcome of ibuprofen by impacting hepatic enzyme CYP2C9/te